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Trial Files: Management of stroke in the setting of Afib and prior DOAC, one day of octreotide for variceal bleed, and semaglutide for alcohol use disorder
Join us on November 5th, 2025, from 4-5 pm for a free crash course on acute kidney injury.Speaker details: Dr. Mike Fralick is a Clinician Scientist who works in Toronto and Sault Ste. Marie.LINK TO FACEBOOK EVENTDIRECT REGISTRATION LINKFor patients with stroke and...
Trial Files: Tirzepatide for HFpEF/Obesity, Bisphosphonates in Early Post-Menopause, CGM vs POCT in Hospital
We want your feedback! Please take a moment to fill out this short, anonymous survey about your experience reading Trial Files. The first 40 respondents will receive a $10 Starbucks gift card. Trial Files Reader SurveyTirzepatide for Heart Failure with Preserved...
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We want to hear from you, our subscribers, about your experiences reading Trial Files. Please complete this short, anonymous survey to let us know what is working and what could could be improved. The first 40 respondents will receive a $10 Starbucks gift card.Access...
Trial Files: Peri-Op ASA for Stable CAD, Semaglutide for Obesity/Knee OA, Renal Outcomes with Finerenone for HF
Aspirin Monotherapy vs No Antiplatelet Therapy in Stable Patients With Coronary Stents Undergoing Low-to-Intermediate Risk Noncardiac Surgery (ASSURE DES)Kang DY et al. JACC (December 2024)Bottom Line: This randomized controlled trial compared the perioperative...
Trial Files: Drugs vs Ablation for VT, O2 Delivery Methods for Resp Failure, and Sepsis Biomarkers for ABx Duration
Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia (VANISH2)Sapp J et al. NEJM (November 2024)Bottom Line: This international trial compared the effectiveness of catheter ablation versus antiarrhythmic drug therapy as a first-line treatment for...
Trial Files Throwback Thursday: Clopidogrel + Aspirin for TIA/Stroke, Stress Testing after PCI, Adjunctive Rifampicin for S. Aureus
What’s the evidence for 21 days of DAPT after TIA or minor stroke?Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE)Wang Y et al. NEJM (July 2013)Bottom Line: This randomized, double-blind, placebo-controlled trial evaluated the...
Trial Files: Transcatheter MV Repair, Disinfecting Medical Equipment, Combination Therapy for Esophageal Varices
Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation (RESHAPE-HF2)Anker S et al. NEJM (August 2024)Bottom Line: This randomized, controlled trial involved 505 patients with heart failure and moderate to severe functional mitral...
Trial Files: Top 5 RCTs for 2024
Check out this week’s episode of The Rounds Table Podcast for a deeper dive into this year’s top 5 RCTs. The Rounds Table PodcastEffects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW)Perkovic V et al. NEJM (May 2024)Bottom...
Trial Files Throwback Thursday: DASH Diet for HTN, Ventilation Volume for ARDS, and MRAs for HFrEF
Why do we recommend a “DASH” diet for patients with hypertension?A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure (DASH)The DASH Collaborative Research Group. NEJM (April 1997)Bottom Line: This randomized controlled trial evaluated the...
Trial Files: Transfusion Targets in Brain Injury, Timing/Frequency of SBT, and Intermittent Fasting for CV Health
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical TrialTaccone F et al. JAMA (October 2024)Bottom Line: This phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial...
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Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files was supported by funding from the Mount Sinai Hospital Department of Medicine Research Fund, the MSH DOM Innovation in Education Awards, and the T-CAIREM Summer Research Program.
