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Trial Files: Pharmacotherapy for MASH, Twice-Yearly Injectable PrEP, Vit D in Clinically Isolated Syndromes
A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis (MAESTRO-NASH)Harrison SA et al. NEJM (February 2024)Bottom Line: This is an ongoing phase 3 clinical trial studying the effectiveness of resmetirom, an oral, liver-directed, thyroid...
Trial Files: Withdrawing Anti-TNFα for IBD in Remission, EVT for Stroke with Medium-Vessel Occlusion, GLP1-RA for Parkinson’s
We want your feedback! Please take a moment to fill out this short, anonymous survey about your experience reading Trial Files. The first 40 respondents will receive a $10 Starbucks gift card. Trial Files Reader SurveyWithdrawal of antitumour necrosis factor in...
Trial Files Throwback Thursday: Rate vs Rhythm Control for A Fib, tPA for Acute Ischemic Stroke, Peripartum Antiretrovirals for HIV
We want your feedback! Please take a moment to fill out this short, anonymous survey about your experience reading Trial Files. The first 40 respondents will receive a $10 Starbucks gift card.Trial Files Reader SurveyWhy has rate control traditionally been preferred...
Trial Files: Tirzepatide for HFpEF/Obesity, Bisphosphonates in Early Post-Menopause, CGM vs POCT in Hospital
We want your feedback! Please take a moment to fill out this short, anonymous survey about your experience reading Trial Files. The first 40 respondents will receive a $10 Starbucks gift card. Trial Files Reader SurveyTirzepatide for Heart Failure with Preserved...
We want your feedback!
We want to hear from you, our subscribers, about your experiences reading Trial Files. Please complete this short, anonymous survey to let us know what is working and what could could be improved. The first 40 respondents will receive a $10 Starbucks gift card.Access...
Trial Files: Peri-Op ASA for Stable CAD, Semaglutide for Obesity/Knee OA, Renal Outcomes with Finerenone for HF
Aspirin Monotherapy vs No Antiplatelet Therapy in Stable Patients With Coronary Stents Undergoing Low-to-Intermediate Risk Noncardiac Surgery (ASSURE DES)Kang DY et al. JACC (December 2024)Bottom Line: This randomized controlled trial compared the perioperative...
Trial Files: Drugs vs Ablation for VT, O2 Delivery Methods for Resp Failure, and Sepsis Biomarkers for ABx Duration
Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia (VANISH2)Sapp J et al. NEJM (November 2024)Bottom Line: This international trial compared the effectiveness of catheter ablation versus antiarrhythmic drug therapy as a first-line treatment for...
Trial Files Throwback Thursday: Clopidogrel + Aspirin for TIA/Stroke, Stress Testing after PCI, Adjunctive Rifampicin for S. Aureus
What’s the evidence for 21 days of DAPT after TIA or minor stroke?Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE)Wang Y et al. NEJM (July 2013)Bottom Line: This randomized, double-blind, placebo-controlled trial evaluated the...
Trial Files: Transcatheter MV Repair, Disinfecting Medical Equipment, Combination Therapy for Esophageal Varices
Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation (RESHAPE-HF2)Anker S et al. NEJM (August 2024)Bottom Line: This randomized, controlled trial involved 505 patients with heart failure and moderate to severe functional mitral...
Trial Files: Top 5 RCTs for 2024
Check out this week’s episode of The Rounds Table Podcast for a deeper dive into this year’s top 5 RCTs. The Rounds Table PodcastEffects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW)Perkovic V et al. NEJM (May 2024)Bottom...
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Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files was supported by funding from the Mount Sinai Hospital Department of Medicine Research Fund, the MSH DOM Innovation in Education Awards, and the T-CAIREM Summer Research Program.
