Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files: Transcatheter MV Repair, Disinfecting Medical Equipment, Combination Therapy for Esophageal Varices
Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation (RESHAPE-HF2)Anker S et al. NEJM (August 2024)Bottom Line: This randomized, controlled trial involved 505 patients with heart failure and moderate to severe functional mitral...
Trial Files: Top 5 RCTs for 2024
Check out this week’s episode of The Rounds Table Podcast for a deeper dive into this year’s top 5 RCTs. The Rounds Table PodcastEffects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW)Perkovic V et al. NEJM (May 2024)Bottom...
Trial Files Throwback Thursday: DASH Diet for HTN, Ventilation Volume for ARDS, and MRAs for HFrEF
Why do we recommend a “DASH” diet for patients with hypertension?A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure (DASH)The DASH Collaborative Research Group. NEJM (April 1997)Bottom Line: This randomized controlled trial evaluated the...
Trial Files: Transfusion Targets in Brain Injury, Timing/Frequency of SBT, and Intermittent Fasting for CV Health
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical TrialTaccone F et al. JAMA (October 2024)Bottom Line: This phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial...
Trial Files: Edoxaban for A Fib/Stable CAD, Finerenone for Preserved EF, and Beta-Blockers after MI
Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease (EPIC-CAD) The EPIC-CAD Investigators. NEJM (September 2024)Bottom line: This multicenter, open-label, adjudicator-masked, randomized trial compared edoxaban monotherapy with...
Trial Files Throwback Thursday: Dialysis in ICU Patients, Bariatric Surgery Referral, and IV PPI for Bleeding Ulcers
Why don’t we prescribe high-intensity dialysis for critically ill patients with acute renal failure? Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients (RENAL) The RENAL Replacement Therapy Study Investigators. NEJM (October 2009) Bottom...
Trial Files: Simultaneous Flu/RSV Vaccines, New Cognitive Screening Tool, Acupuncture for Spinal Stenosis
Safety and Immunogenicity of Respiratory Syncytial Virus Prefusion F Protein Vaccine when Co-administered with Adjuvanted Seasonal Quadrivalent Influenza Vaccine in Older Adults: A Phase 3 Randomized Trial Clark R et al. Clinical Infectious Diseases (August 2024)...
Trial Files Throwback Thursday: Sodium Bicarbonate for CKD, ASA+DOAC for PAD, Anti-Fibrotics for IPF
What's the rationale for giving sodium bicarbonate to patients with CKD and metabolic acidosis? Bicarbonate Supplementation Slows Progression of CKD and Improves Nutritional Status de Brito-Ashurst I et al. JASN (September 2009) Bottom line:This randomized controlled...
Trial Files: Triple Combo Pill for T2DM, Personalized Diet for CV Health, G-CSF for Alcoholic Hepatitis
Efficacy and tolerability of initial triple combination therapy with metformin, dapagliflozin and saxagliptin compared with stepwise add-on therapy in drug-naïve patients with type 2 diabetes (TRIPLE-AXEL study): A multicentre, randomized, 104-week, open-label,...
Trial Files Throwback Thursday: Inhalers for Mild Asthma, Naltrexone for AUD, Cytoreduction for PV
Introducing Diabetes Trial Files, for all of your diabetes RCT needs. Check out the first issue below and subscribe (for free!). Diabetes Trial Files Issue #1 What's the evidence for using as-needed budesonide-formoterol instead of salbutamol for mild asthma?...
About
Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files was supported by funding from the Mount Sinai Hospital Department of Medicine Research Fund, the MSH DOM Innovation in Education Awards, and the T-CAIREM Summer Research Program.
