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Trial Files: Top 5 RCTs for 2024
Check out this week’s episode of The Rounds Table Podcast for a deeper dive into this year’s top 5 RCTs. The Rounds Table PodcastEffects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW)Perkovic V et al. NEJM (May 2024)Bottom...
Trial Files: MTX for Knee OA, Dual Cardioversion for A Fib, and Tenecteplase at 4.5-24 hrs
Launching this week: Diabetes Trial Files, for all of your diabetes RCT needs. Subscribe below to receive the first issue (for free!). Sign Up: Diabetes Trial Files Pain Reduction With Oral Methotrexate in Knee Osteoarthritis: A Randomized, Placebo-Controlled...
Trial Files Throwback Thursday: ACEi for Diabetic Nephropathy, Antiplts for PAD, Bisphosphonates for Bony Mets
Why is ACE inhibition recommended for patients with diabetic nephropathy? The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy Lewis E et al. NEJM (November 1993) Bottom line: This randomized, controlled trial compared the effects of...
Trial Files: A Biologic for COPD, Feedback on ABx Prescribing, Remote Care Post-ACS
Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation (NOTUS) Bhatt S et al. NEJM (May 2024) Bottom line: This phase 3, double-blind, randomized trial evaluated the efficacy and safety of subcutaneous dupilumab (300 mg) versus placebo every 2...
Trial Files Throwback Thursday: Treating VTE in Cancer, Hydralazine/ISDN for HFrEF, and Surgery for IE
In patients with cancer, how does LMWH compare to warfarin for preventing recurrent VTE? Low-Molecular-Weight Heparin versus a Coumarin for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Lee A et al. NEJM (July 2003) Bottom...
Trial Files: β-Blockers after MI, Early Mgmt of Asthma/COPD, AI-Generated ECG Alerts
Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction (REDUCE-AMI) Yndigegn T et al. NEJM (April 2024) Bottom line: This parallel-group, open-label trial enrolled 5020 patients with acute myocardial infarction and preserved left ventricular...
Trial Files Throwback Thursday: Treatment Choice for Status Epilepticus, Pre-Op Revascularization for Stable CAD, and Hydroxyurea to Prevent Sickle Cell Pain Crises
How did lorazepam come to be a first-line agent for treating status epilepticus? A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus Treiman D et al. NEJM (September 1998) Bottom line: This five-year randomized, double-blind,...
Trial Files: Reducing Contrast-Induced AKI after ACS, Antibiotic Stewardship for Pneumonia, and Peri-operative Management of RAAS Blockade
Kidney Injury After Minimal Radiographic Contrast Administration in Patients With Acute Coronary Syndromes Briguori C et al. JACC (March 2024) Bottom line: This randomized, single-blind, investigator-driven clinical trial evaluated the effectiveness of the...
Trial Files Throwback Thursday: Furosemide Dosing in CHF, Magnesium for Eclampsia Prevention, and Prone Positioning for ARDS
What’s the evidence behind different dosing strategies of diuretics in patients with decompensated heart failure? Diuretic Strategies in Patients with Acute Decompensated Heart Failure (DOSE) Felker G et al. NEJM (March 2011) Bottom line: This was a...
Trial Files: Standing Up to Bring BP Down, O2 Targets in ICU Patients with COVID, and Integrated Care for Hep C/Opioid Use
Sitting Time Reduction and Blood Pressure in Older Adults Rosenberg D et al. JAMA (March 2024) Bottom line: This parallel-group randomized clinical trial examined the efficacy of a sedentary behaviour reduction intervention in older adults. A total of 283...
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Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files was supported by funding from the Mount Sinai Hospital Department of Medicine Research Fund, the MSH DOM Innovation in Education Awards, and the T-CAIREM Summer Research Program.
