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Trial Files Throwback: Why do we use apixaban over aspirin in afib? Why do we treat alcohol withdrawal based on symptoms, rather than a fixed schedule?
What is the evidence for the use of apixaban over aspirin in patients with afib? Apixaban in Patients with Atrial FibrillationThe AVERROES Trial. NEJM (March 2011)Bottom Line: This randomized, double-blind trial compared apixaban with aspirin in 5599 patients with...
Trial Files: Baxdrostat in Uncontrolled and Resistant HTN, Telitacicept for SLE and Orforglipron in T2DM
Join us on November 5th, 2025, from 4-5 pm for a free crash course on acute kidney injury.Speaker details: Dr. Mike Fralick is a Clinician Scientist who works in Toronto and Sault Ste. Marie.LINK TO FACEBOOK EVENTDIRECT REGISTRATION LINKDo aldosterone synthase...
Trial Files: Management of stroke in the setting of Afib and prior DOAC, one day of octreotide for variceal bleed, and semaglutide for alcohol use disorder
Join us on November 5th, 2025, from 4-5 pm for a free crash course on acute kidney injury.Speaker details: Dr. Mike Fralick is a Clinician Scientist who works in Toronto and Sault Ste. Marie.LINK TO FACEBOOK EVENTDIRECT REGISTRATION LINKFor patients with stroke and...
Trial Files Throwback: Why don’t we target a hemoglobin of 130 g/L in CKD? Why don’t we do Swans anymore? And how long should we monitor for afib post cryptogenic stroke?!
Join us on November 5th, 2025, from 4-5 pm for a free crash course on acute kidney injury. Speaker details: Dr. Mike Fralick is a Clinician Scientist who works in Toronto and Sault Ste. Marie. LINK TO FACEBOOK EVENT DIRECT REGISTRATION LINK Why is targeting a...
Trial Files Guidelines Edition: KDIGO 2024 Evaluation and Management of CKD
These guidelines were published in 2024 and span nearly 200 pages. LINK TO GUIDELINES Top 3 Take Home Points Risk-based care is central. Use eGFR and albuminuria for staging CKD— this combination predicts outcomes better than either alone. This dual approach enables...
ESC 2025 Special Edition: Extended Treatment of Apix for Provoked VTE, RSV Vaccine to Prevent Hospitalization,& Digitoxin for HFrEF
The European Society of Cardiology (ESC) Conference took place Aug 29 to Sep 1, 2025, and had multiple practice changing RCTs. This issue will showcase 3 important new publications. Should patients with provoked VTE receive more than 3 months of apixaban? Apixaban for...
Trial Files Throwback: When should dialysis be started in ESRD?, Bariatric Surgery cures Diabetes, and Prone Positioning in Severe ARDS
Join us on September 4th, 2025, from 12-1 pm for a free crash course on anemia and thrombocytopenia. Speaker details: Dr. Mike Fralick is a Clinician Scientist who works in Toronto and Sault Ste. Marie. LINK TO FACEBOOK EVENT DIRECT REGISTRATION LINK Early dialysis is...
Trial Files: Liberal fluid intake vs fluid restriction in chronic heart failure, Semaglutide in MASH and First Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate
Should fluid restriction truly be recommended in chronic heart failure? Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (FRESH-UP) Herrmann JJ et al. Nature Medicine (March 2025) Bottom Line: This multicenter...
Trial Files: Tirzepatide vs Semaglutide for Obesity, Obicetrapib for patients at High Cardiovascular risk and Albuterol–Budesonide in Mild Asthma
Tirzepatide beats semaglutide when it comes to weight loss! Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (SURMOUNT-5) Aronne LJ et al. NEJM (May 2025) Bottom Line: This phase 3b, open-label, controlled trial evaluated the efficacy and safety...
Trial Files Throwback: Aspirin after TAVI, lack of benefit of sodium bicarbonate for severe metabolic acidaemia, beta-lactams alone for CAP
Join us on July 17th, 2025, from 12-1 pm for a free crash course on antibiotics and updates in the management of bacteremia. Speaker details: Dr. Mike Fralick is a Clinician Scientist who works in Toronto and Sault Ste. Marie. He was a site lead for the recently...
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Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files was supported by funding from the Mount Sinai Hospital Department of Medicine Research Fund, the MSH DOM Innovation in Education Awards, and the T-CAIREM Summer Research Program.
