Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
ESC 2025 Special Edition: Extended Treatment of Apix for Provoked VTE, RSV Vaccine to Prevent Hospitalization,& Digitoxin for HFrEF
The European Society of Cardiology (ESC) Conference took place Aug 29 to Sep 1, 2025, and had multiple practice changing RCTs. This issue will showcase 3 important new publications. Should patients with provoked VTE receive more than 3 months of apixaban? Apixaban for...
Trial Files Throwback Thursday: Anti-hypertensives to Prevent Stroke, IV Iron for HFrEF, and Duration of ABx for Intra-abdo Infection
Why are perindopril and indapamide the preferred anti-hypertensives for patients with stroke/TIA? Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack (PROGRESS) PROGRESS...
Trial Files: Early DAPT after TIA/Minor Stroke, Automatic Palliative Care Consultation, and Transfusion Threshold after MI
Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke (INSPIRES) Gao Y et al. NEJM (December 2023) Bottom line: This double-blind, randomized, placebo-controlled, two-by-two factorial trial was conducted in 222 hospitals in China. The study included...
Trial Files Throwback Thursday: Making Decisions Under Pressor, Oral ABx in Osteomyelitis, and DOACs to Treat Cancer-Associated VTE
FEB 08, 2024 Share Why should I use norepinephrine as my first-line vasopressor in shock? Comparison of Dopamine and Norepinephrine in the Treatment of Shock (SOAP II) De Backer D et al. NEJM (March 2010) Bottom line: This is a multicenter, randomized trial...
Trial Files: IV Iron Before Surgery, Tirzepatide to Maintain Weight Loss, and The Effect of a Chair at the Bedside
Intravenous iron administration before cardiac surgery reduces red blood cell transfusion in patients without anaemia Friedman T et al. British Journal of Anaesthesia (December 2023) Bottom line: This double-blind, randomised, placebo-controlled trial included...
Trial Files Throwback Thursday: Dexamethasone for COVID, Thresholds for RBC Transfusion, and PCI in Stable CAD
What is the evidence behind treating patients with COVID pneumonia and hypoxia with dexamethasone? Dexamethasone in Hospitalized Patients with Covid-19 (RECOVERY) The RECOVERY Collaborative Group. NEJM (February 2021) Bottom line: This was a controlled,...
Trial Files: Inpatient Initiation of Hep C Treatment, Small-Volume Phlebotomy to Reduce Transfusions, and A Potential PPI Alternative for GERD
Opportunistic Treatment of Hepatitis C Infection Among Hospitalized People Who Inject Drugs (OPPORTUNI-C) Midgard H et al. Clinical Infectious Diseases (November 2023) Bottom line: This was a pragmatic, stepped wedge cluster randomized trial to evaluate the...
Trial Files Throwback Thursday: Upfront Management of Septic Shock, CIWA for Alcohol Withdrawal, and Dexamethasone for Bacterial Meningitis
Introducing IBD Trial Files, for all of your inflammatory bowel disease RCT needs. Check out the first issue below and subscribe (for free!).IBD Trial Files Issue #1What is the evidence behind using early, targeted therapy for my patients presenting with...
Trial Files: Virtual Pre-Op Assessments, Acetazolamide in CHF, and Convalescent Immunoglobulins in COVID-19
Effectiveness of a digital vs face-to-face preoperative assessment: A randomized, noninferiority clinical trialvan Hoorn B et al. Journal of Clinical Anesthesia (November 2023)Bottom line: This was a single center, randomized (1:1), parallel, open-label,...
About
Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files was supported by funding from the Mount Sinai Hospital Department of Medicine Research Fund, the MSH DOM Innovation in Education Awards, and the T-CAIREM Summer Research Program.
