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Trial Files Guidelines Edition: KDIGO 2024 Evaluation and Management of CKD
These guidelines were published in 2024 and span nearly 200 pages. LINK TO GUIDELINES Top 3 Take Home Points Risk-based care is central. Use eGFR and albuminuria for staging CKD— this combination predicts outcomes better than either alone. This dual approach enables...
Trial Files Throwback Thursday: Treating VTE in Cancer, Hydralazine/ISDN for HFrEF, and Surgery for IE
In patients with cancer, how does LMWH compare to warfarin for preventing recurrent VTE? Low-Molecular-Weight Heparin versus a Coumarin for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Lee A et al. NEJM (July 2003) Bottom...
Trial Files: β-Blockers after MI, Early Mgmt of Asthma/COPD, AI-Generated ECG Alerts
Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction (REDUCE-AMI) Yndigegn T et al. NEJM (April 2024) Bottom line: This parallel-group, open-label trial enrolled 5020 patients with acute myocardial infarction and preserved left ventricular...
Trial Files Throwback Thursday: Treatment Choice for Status Epilepticus, Pre-Op Revascularization for Stable CAD, and Hydroxyurea to Prevent Sickle Cell Pain Crises
How did lorazepam come to be a first-line agent for treating status epilepticus? A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus Treiman D et al. NEJM (September 1998) Bottom line: This five-year randomized, double-blind,...
Trial Files: Reducing Contrast-Induced AKI after ACS, Antibiotic Stewardship for Pneumonia, and Peri-operative Management of RAAS Blockade
Kidney Injury After Minimal Radiographic Contrast Administration in Patients With Acute Coronary Syndromes Briguori C et al. JACC (March 2024) Bottom line: This randomized, single-blind, investigator-driven clinical trial evaluated the effectiveness of the...
Trial Files Throwback Thursday: Furosemide Dosing in CHF, Magnesium for Eclampsia Prevention, and Prone Positioning for ARDS
What’s the evidence behind different dosing strategies of diuretics in patients with decompensated heart failure? Diuretic Strategies in Patients with Acute Decompensated Heart Failure (DOSE) Felker G et al. NEJM (March 2011) Bottom line: This was a...
Trial Files: Standing Up to Bring BP Down, O2 Targets in ICU Patients with COVID, and Integrated Care for Hep C/Opioid Use
Sitting Time Reduction and Blood Pressure in Older Adults Rosenberg D et al. JAMA (March 2024) Bottom line: This parallel-group randomized clinical trial examined the efficacy of a sedentary behaviour reduction intervention in older adults. A total of 283...
Trial Files Throwback Thursday: Albumin for Large-Volume Paracentesis, Target BP in Pregnancy, and Early Combination Therapy for RA
Why should I give albumin after large-volume paracentesis in patients with cirrhosis? Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis Ginès P et al. Gastroenterology (June 1988) Bottom line: This...
Trial Files: Antivirals for COVID in Pregnancy, Denosumb for Erosive Osteoarthritis, and Choice of SAPT > 1 Year After PCI
Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 Omicron infection: a target trial emulation Wong C et al. Nature Medicine (November 2023) Bottom line: This is a target trial emulation study that evaluated the use of nirmatrelvir/ritonavir in...
Trial Files: Antivirals for COVID in Pregnancy, Denosumb for Erosive Osteoarthritis, and Choice of SAPT > 1 Year After PCI
Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 Omicron infection: a target trial emulationWong C et al. Nature Medicine (November 2023)Bottom line: This is a target trial emulation study that evaluated the use of nirmatrelvir/ritonavir in...
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Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files was supported by funding from the Mount Sinai Hospital Department of Medicine Research Fund, the MSH DOM Innovation in Education Awards, and the T-CAIREM Summer Research Program.
