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Trial Files: Baxdrostat in Uncontrolled and Resistant HTN, Telitacicept for SLE and Orforglipron in T2DM
Join us on November 5th, 2025, from 4-5 pm for a free crash course on acute kidney injury.Speaker details: Dr. Mike Fralick is a Clinician Scientist who works in Toronto and Sault Ste. Marie.LINK TO FACEBOOK EVENTDIRECT REGISTRATION LINKDo aldosterone synthase...
Trial Files Throwback Thursday: Thoracentesis in Acute Heart Failure, Reldesemtiv in ALS and Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes
Looking for a book that covers all things inpatient medicine? One-Pagers for the Wards is a concise, high-yield resource offering single-page summaries of internal medicine workups, treatments, and clinical pearls tailored for inpatient medicine. LINK TO ONE-PAGERS...
Trial Files Turns Two: Top 5 Trials Over the Past 2 Years
Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia Carson JL et al. NEJM (November 2023) Bottom Line: This phase 3 interventional trial compared a liberal transfusion strategy (hemoglobin cutoff, <10 g/dL) to a restrictive transfusion...
Trial Files Throwback Thursday: Opioids vs Non-Opioids for Chronic Pain, IV Albumin For Spontaneous Bacterial Peritonitis, and PPI for GI Bleed
Are non-opioids effective for chronic back pain or hip or knee osteoarthritic pain? Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain (SPACE) Krebs EE et al. JAMA (March 2018)...
Trial Files: CGM in Older Patients with T1DM, Left Atrial Appendage Closure after Ablation for AFib and Alteplase for Posterior Circulation Ischemic Stroke at 4.5-24 Hrs
Continuous Glucose Monitoring With Geriatric Principles in Older Adults With Type 1 Diabetes and Hypoglycemia: A Randomized Controlled Trial Munshi MN et al. Diabetes Care (September 2024) Bottom Line: This randomized controlled trial included 131 older adults (≥65...
Trial Files Throwback Thursday: Inhalers for COPD, EVT for Acute Ischemic Stroke, Remdesevir for COVID-19
Why is LABA-LAMA preferred over LABA-ICS for preventing COPD exacerbations? Indacaterol–Glycopyrronium versus Salmeterol–Fluticasone for COPD (FLAME) Wedzicha JA et al. NEJM (June 2016) Bottom Line: This 52-week, randomized, double-blind, double-dummy, noninferiority...
Trial Files: Biomarkers vs Doppler for IUGR, Impact of A1c Variability on BP Control, Transitioning Care after AKI
Angiogenic factors versus fetomaternal Doppler for fetal growth restriction at term: an open-label, randomized controlled trial Garcia-Manau P et al. Nature Medicine (January 2025) Bottom Line: This randomized controlled trial compared the use of abnormal serum...
Trial Files: Pharmacotherapy for MASH, Twice-Yearly Injectable PrEP, Vit D in Clinically Isolated Syndromes
A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis (MAESTRO-NASH)Harrison SA et al. NEJM (February 2024)Bottom Line: This is an ongoing phase 3 clinical trial studying the effectiveness of resmetirom, an oral, liver-directed, thyroid...
Trial Files: Withdrawing Anti-TNFα for IBD in Remission, EVT for Stroke with Medium-Vessel Occlusion, GLP1-RA for Parkinson’s
We want your feedback! Please take a moment to fill out this short, anonymous survey about your experience reading Trial Files. The first 40 respondents will receive a $10 Starbucks gift card. Trial Files Reader SurveyWithdrawal of antitumour necrosis factor in...
Trial Files Throwback Thursday: Rate vs Rhythm Control for A Fib, tPA for Acute Ischemic Stroke, Peripartum Antiretrovirals for HIV
We want your feedback! Please take a moment to fill out this short, anonymous survey about your experience reading Trial Files. The first 40 respondents will receive a $10 Starbucks gift card.Trial Files Reader SurveyWhy has rate control traditionally been preferred...
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Free monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox. Sign up here.
Trial Files was supported by funding from the Mount Sinai Hospital Department of Medicine Research Fund, the MSH DOM Innovation in Education Awards, and the T-CAIREM Summer Research Program.
